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. 2020 Nov 11;221:107745. doi: 10.1016/j.pharmthera.2020.107745

Fig. 1.

Fig. 1

Time course of immune activation following SARS-CoV-2 viral infection in the context of p38 MAP kinase activation. In essence, many of the pathological events underpinning mortality following SARS-CoV-2 infection including neutrophilic and monocytic infiltrates, cytokine storm, oedema formation and clotting as well as risk factors are driven by elevated p38 MAP kinase activity.