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Tobacco Heating System (THS) 2.2 aerosol induces fewer miRNA changes in the respiratory tract than cigarette smoke. miRNA expression profiles across tissues are shown. Top 10 high-confidence miRNAs correlated with 3R4F CS response in MOFA models in each tissue selected for visualization. (A) miRNA expression across tissues. Max fold change and % significant time points visualized. (B) Differential miRNA expression for the RNE, (C) larynx, and (D) lungs.
