Figure 8.

Tobacco Heating System (THS) 2.2 aerosol is associated with lower macrophage and neutrophil numbers and activation in the lungs than cigarette smoke. A, Network enrichment for the neutrophil and macrophage signaling networks in the lungs. The bars show the overall network perturbation amplitude calculated from transcriptomic data; error bars denote 95% confidence intervals. Three statistical measures are shown: The red, green (o statistic), and blue (k statistic) stars indicate statistical significance with respect to biological replicates, permutation of genes downstream of the network nodes, and permutation of the network topology, respectively (p-value < .05). B, Macrophage and neutrophil counts in bronchoalveolar lavage fluid as markers of inflammation plotted against the corresponding network perturbation amplitude scores from panel I. IPN, inflammatory process network.