Table 1.
Tissues and Main Endpoints
| Tissue | Endpoint | Time Pointsa (months) |
|---|---|---|
| Respiratory nasal epithelium | Histopathology | 1 m (N = 11), 5 m (N = 12), 10 m (N = 11–12), 18 m (N = 54–99) |
| mRNA expression | 1 m (N = 8), 5 m (N = 8), 10 m (N = 10–12), 18 m (N = 16–20) | |
| miRNA expression | 1 m (N = 8), 5 m (N = 8), 10 m (N = 10–12), 18 m (N = 16–20) | |
| Protein expression | 1 m (N = 8), 5 m (N = 8), 10 m (N = 10–12), 18 m (N = 16–20) | |
| Larynx | Histopathology | 1 m (N = 10–11), 5 m (N = 11–12), 10 m (N = 11–12), 18 m (N = 54–95) |
| mRNA expression | 1 m (N = 8), 5 m (N = 8), 10 m (N = 10–12), 18 m (N = 16–20) | |
| miRNA expression | 1 m (N = 8), 5 m (N = 8), 10 m (N = 10–12), 18 m (N = 16–20) | |
| Lung | Histopathology | 1 m (N = 10–11), 5 m (N = 12), 10 m (N = 11–12), 18 m (N = 53–98) |
| mRNA expression | 1 m (N = 8), 5 m (N = 8), 10 m (N = 10–12), 18 m (N = 16–20) | |
| miRNA expression | 1 m (N = 8) | |
| Protein expression | 1 m (N = 8) |
a
Number of replicates (N) refers to the number of animals.