Figure 7.

Heatmap of the effects of cys-loop antagonists (green, from top to bottom: pentylenetetrazol, picrotoxin [PTX], amoxapine, and strychnine) on human-induced pluripotent stem cell (hiPSC)-derived neuronal cocultures (black, top) and rat primary cortical cultures (gray, bottom). Color scaling is based on the percentage of change relative to the control with red indicating an increase and blue a decrease. Asterisks indicate a hit. White areas indicate that no average could be calculated. Data are based on n = 1–17 wells for hiPSC-derived neuronal cocultures and n = 9–32 wells for rat primary cortical cultures. PTX and strychnine data have been published previously in Tukker et al. (2020).