Table 2.
Description of Different Metric Parameters
| Metric Parameter | Description | Coding | |
|---|---|---|---|
| Spike parameters | MSR | Total number of spikes divided by recording time (Hz) | S1 |
| ISI CoV | SD ISI (time between spikes) divided by the mean ISI. Measure for spike regularity: 0 indicates perfect spike distribution, >1 signals bursting | S2 | |
| Burst parameters | MBR | Total number of bursts divided by recording time (Hz). | B1 |
| Burst duration | Average time from the first spike in a burst till the last spike (s) | B2 | |
| Number of spikes per burst | Average number of spikes occurring in a burst | B3 | |
| Mean ISI within burst | Mean ISI within a burst (s) | B4 | |
| Median ISI within burst | Median ISI within a burst (s) | B5 | |
| Median/mean ISI within burst | Median / mean ISI within a burst. Values close to 1 indicate a symmetric distribution of spikes within a burst | B6 | |
| IBI | Time between the last spike of a burst and the first spike of a subsequent burst (s) | B7 | |
| IBI CoV | Standard deviation of IBI divided by the mean IBI. Measure for burst regularity | B8 | |
| Burst percentage | Percentage of total number of spikes occurring in a burst | B9 | |
| Network burst parameters | MNBR | Total number of network bursts divided by recording time (Hz) | N1 |
| Network burst duration | Average time from the first spike till the last spike in a network burst (s) | N2 | |
| Number of spikes per network burst | Average number of spikes occurring in a network burst | N3 | |
| Mean ISI within network burst | Average of the mean ISIs within a network burst (s) | N4 | |
| Median ISI within network burst | Median ISI within a network burst (s) | N5 | |
| Median/mean ISI within network burst | Median / mean ISI within a network burst. Values close to 1 indicate a symmetric distribution of spikes within a burst | N6 | |
| Number of electrodes participating in network burst | Average number of electrodes with spikes that participate in the network burst | N7 | |
| Number of spikes per network burst per channel | Average number of spikes in a network burst, divided by the number of electrodes that participate in the network burst | N8 | |
| Network burst percentage | Percentage of total spikes occurring in a network burst | N9 | |
| Network IBI CoV | Standard deviation of network IBI divided by the mean network IBI. Measure of network burst rhythmicity: value is small when bursts occur at regular interval and increases when bursts occur more sporadic | N10 | |
| Network normalized duration IQR | Interquartile range of network bursts durations. Measure for network burst duration regularity: larger values indicate wide variation in duration | N11 | |
| Synchronicity parameters | Area under normalized cross-correlation | Area under interelectrode cross-correlation normalized to the auto-correlations. The higher the value, the greater the synchronicity of the network | Sy1 |
| Area under cross-correlation | Area under interelectrode cross-correlation | Sy2 | |
| Full width at half height (FWHH) of normalized cross-correlation | Width at half left height of the normalized cross-correlogram to half right height. Measure for network synchrony: the higher the value, the less synchronized the network is | Sy3 | |
| FWHH of cross-correlation | Width at half left height of the cross-correlogram to the half right height | Sy4 |
Adapted from Tukker et al. (2020). Parameters in italic are included in the PCA.