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. 2020 Nov 11;39:239. doi: 10.1186/s13046-020-01750-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — PLK2 is significantly down-regulated in TMZ resistant GBM. a, Microarray analysis for differentially expressed kinases (DEKs) in TMZ resistant cells versus Naïve cells using GEO database (GSE68029). b, Microarray analysis for DEKs in GBM versus non-tumor tissues in GEO database (GSE16011). c, Differential kinase expression analysis in GBM versus non-tumor tissues using TCGA GBM dataset. d, Venn diagram for down-regulated kinases in both three datasets of comparisons, indicating PLK2 was one of the most significantly down-regulated kinases in TMZ resistant cells as well as GBM tissues