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. 2020 Nov 11;39:239. doi: 10.1186/s13046-020-01750-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Decreased PLK2 expression is closely associated with poor outcomes in glioma patients. a, Gene expression analysis using TCGA GBM database (*P < .05, with student’s t-test). b, Gene expression analysis with Rembrandt database in different types of glioma versus non-tumor (*P < .05, **P < .01, ***P < .001, with one-way ANOVA followed by Dunnett’s posttest). c, Gene expression analysis with TCGA GBM dataset in different subtypes of GBM versus non-tumor (***P < .001, with one-way ANOVA followed by Dunnett’s posttest). d. Kaplan-Meier analysis for PLK2 expression using GBM patient samples (P < .0001, with log-rank test). e, Kaplan-Meier analysis for PLK2 expression in Rembrandt dataset by dividing glioma samples into 3 groups including PLK2^high, PLK2^mid, PLK2^low (with log-rank test within each comparison)