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. 2020 Nov 11;39:239. doi: 10.1186/s13046-020-01750-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Loss of PLK2 enhances TMZ resistance of GBM via activation of Notch signaling. a and b, Hierarchical bi-clustering analysis was performed by using GEO database (GSE16011) or TCGA GBM database, indicating the significant gene signature in PLK2^high GBM compared with PLK2^low GBM. c and d, Bubble plots were carried out to illustrate the results of GSEA analyses using the transcriptome profiles of GSE16011 and TCGA GBM, indicating that PLK2 was negatively correlated with these pathways. e, Venn diagram of all significantly enriched pathways that are negatively correlated with PLK2 from GSEA analyses, showing Notch signaling pathway was the only common pathway that is negatively correlated with PLK2. f, GSEA plot showed the negative correlation between PLK2 and Notch signaling pathway