Table 1.
Effect of early tranexamic acid on all-cause mortality within 24 h of injury, after 24 h and at 28 days stratified by severity and country income level in patients randomised within 3 h of injury, excluding those with a GCS score of 3 or bilateral unreactive pupils
| Within 24 h | After 24 h | At 28 days | |||||||
|---|---|---|---|---|---|---|---|---|---|
| TXA | Placebo | RR (95% CI) | TXA | Placebo | RR (95% CI) | TXA | Placebo | RR (95% CI) | |
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | ||||
| All patients | 112 (2.9) | 147 (3.9) | 0.74 (0.58–0.94) | 432 (11.5) | 421 (11.7) | 0.98 (0.69–1.12) | 544 (14.0) | 568 (15.1) | 0.93 (0.83–1.03) |
| Severity | |||||||||
| Mild/moderate | 25 (0.9) | 37 (1.3) | 0.66 (0.40–1.09) | 163 (5.8) | 186 (6.9) | 0.85 (0.69–1.04) | 188 (6.7) | 223 (8.1) | 0.82 (0.68–0.99) |
| Severe | 87 (8.5) | 110 (11.3) | 0.75 (0.58–0.98) | 269 (28.7) | 235 (27.2) | 1.05 (0.91–1.22) | 356 (34.7) | 345 (35.4) | 0.98 (0.87–1.10) |
| Country income | |||||||||
| LMIC | 98 (3.3) | 126 (4.4) | 0.75 (0.58–0.98) | 363 (12.6) | 344 (12.5) | 1.01 (0.88–1.16) | 461 (15.5) | 470 (16.3) | 0.95 (0.84–1.07) |
| HIC | 14 (1.5) | 21 (2.4) | 0.65 (0.33–1.26) | 69 (7.7) | 77 (9.0) | 0.86 (0.63–1.18) | 83 (9.2) | 98 (11.1) | 0.82 (0.62–1.08) |