Table 1.
Utility of Genetic Profiling in Terms of AUC and Percentage of Net Reclassification Improvement
| Number of variants | AUC | ||||
|---|---|---|---|---|---|
| OR = 1.10 | OR = 1.15 | OR = 1.20 | OR = 1.25 | OR = 1.30 | |
| 10 | 0.557 | 0.586 | 0.611 | 0.635 | 0.659 |
| 50 | 0.630 | 0.682 | 0.733 | 0.769 | 0.805 |
| 100 | 0.682 | 0.743 | 0.794 | 0.841 | 0.870 |
| 500 | 0.830 | 0.898 | 0.936 | 0.953 | 0.967 |
| 1000 | 0.895 | 0.943 | 0.966 | 0.977 | 0.983 |
Notes. Results were obtained by simulation with the following parameters: gene frequency = 0.5, risk threshold = 0.2, and 5‐year incidence of fracture = 0.1. AUC = Area under the receiver operating characteristic curve; OR = odds ratio.