Table 2.
Bone Resorptive Activity of OCs in vitro Correlates With the Smoking Status and the Number of Nuclei per OC
| Dependent variable | R 2 | Independent variable | Coefficient | SE | t | P Value |
|---|---|---|---|---|---|---|
| IC50_log a | 0.30 | Age (years) | −0.001 | 0.03 | −0.00 | 0.997 |
| Menopause (0 = post‐, 1 = pre‐) | 0.613 | 0.46 | 1.34 | 0.190 | ||
| Height (m) | −2.213 | 3.10 | −0.71 | 0.480 | ||
| Weight (kg) | −0.002 | 0.01 | −0.15 | 0.880 | ||
| Smoking (0 = no, 1 = yes) | 1.289 | 0.47 | 2.73 | 0.010* | ||
| Comorbidity (0 = no, 1 = yes) | −0.118 | 0.42 | −0.28 | 0.779 | ||
| CTx in vivo (ng/mL) | −0.964 | 1.52 | −0.63 | 0.530 | ||
| PINP in vivo (ng/mL) | 0.022 | 0.02 | 1.39 | 0.174 | ||
| #OCs | 0.002 | 0.01 | 0.41 | 0.686 | ||
| #nuclei/OC | 0.314 | 0.14 | 2.28 | 0.029* | ||
| _cons | 0.375 | 5.32 | 0.07 | 0.944 |
a
Based on total eroded bone surface after 3 days of resorption.