Fig. 3. A significant interaction between inflammation (as measured by a composite factor for cytokines and their soluble receptors) and FC with respect to their relationship with symptoms of anhedonia was observed. Specifically, VS-vmPFC (LVS-vmPFC) FC was negatively associated with anhedonia as measured by the BDI anhedonia subscale (A) and the PSS avoidance/numbing subscale (B), with lower LVS-vmPFC FC predicting increased symptom severity in women with (solid circles) but not without (open circles) an inflammatory composite score above the median. Of note, one subject did not complete one item on the BDI anhedonia subscale (see Supplement) and one subject had an anhedonia score >4 s.d. above the mean, thus n = 15/group in A and 16/group in B.