Table 2. VACO Index development cohort unadjusted associations with 30-day mortality (n = 3,681; 480 deaths).

	Odds Ratio	95% CI	P-value
Demographics
Age, in years
20–49	0.08	(0.02–0.39)	0.002
50–54	Reference	-	-
55–59	1.60	(0.71–3.59)	0.254
60–64	2.95	(1.41–6.14)	0.004
65–69	4.83	(2.35–9.89)	<0.001
70–74	7.02	(3.51–14.03)	<0.001
75–79	8.22	(4.00–16.89)	<0.001
80–89	14.45	(7.15–29.21)	<0.001
≥90	23.48	(11.05–49.88)	<0.001
Race/Ethnicity
Non-Hispanic White	Reference	-	-
Non-Hispanic Black	0.71	(0.58–0.88)	0.001
Hispanic	0.58	(0.41–0.84)	0.003
Other/Unknown	0.52	(0.31–0.88)	0.015
Male sex	4.67	(2.38–9.13)	<0.001
Comorbidity
Asthma	0.85	(0.56–1.28)	0.437
Hypertension	2.65	(2.09–3.35)	<0.001
Charlson Comorbidities
AIDS	1.13	(0.59–2.16)	0.708
Cancer	1.63	(1.27–2.09)	<0.001
Cancer, metastatic	1.46	(0.79–2.68)	0.224
Cerebrovascular accident	1.96	(1.54–2.50)	<0.001
Chronic pulmonary disease	1.53	(1.24–1.88)	<0.001
Congestive heart failure	2.32	(1.86–2.90)	<0.001
Diabetes	1.73	(1.43–2.10)	<0.001
Diabetes with complications	2.02	(1.64–2.47)	<0.001
Dementia	3.25	(2.57–4.11)	<0.001
Liver disease, mild	0.82	(0.60–1.13)	0.226
Liver disease, severe	3.39	(1.69–6.83)	0.001
Myocardial infarction	2.33	(1.69–3.22)	<0.001
Peptic ulcer disease	1.55	(0.82–2.93)	0.175
Peripheral vascular disease	2.74	(2.20–3.42)	<0.001
Plegia	1.00	(0.49–2.03)	0.999
Renal Disease	2.51	(2.04–3.09)	<0.001
Rheumatologic disease	1.86	(1.08–3.21)	0.026
Charlson Comorbidity Index
0	Reference	-	-
1–3	3.91	(2.71–5.65)	<0.001
4–5	6.33	(4.23–9.46)	<0.001
6–9	8.12	(5.46–12.06)	<0.001
≥10	9.54	(5.41–16.83)	<0.001
Charlson Comorbidity Index and Age Interaction Term
Age <85
Charlson Comorbidity Index
0	Reference	-	-
1–3	3.77	(2.48–5.73)	<0.001
4–5	7.12	(4.52–11.21)	<0.001
6–9	8.63	(5.51–13.52)	<0.001
≥10	13.65	(7.49–24.90)	<0.001
Age 85+, any Charlson Comorbidity Index value	25.38	(16.17–39.82)	<0.001

Abbreviations: CI = confidence interval, IQR = interquartile range, AIDS = acquired immunodeficiency syndrome