Table 3. Correlation of the tumor profile and survival with the miR expression.
| Characteristics | Total N = 50 n (%) | miR-18a Over expression (≥ 8.84) N = 20 n (%) | miR-18a Under expression (< 8.84) N = 30 n (%) | p- value | miR-182 Over expression (≥ 6.32) N = 18 n (%) | miR-182 Under expression (< 6.32) N = 32 n (%) | p- value |
|---|---|---|---|---|---|---|---|
| Age (years) | 0.71 | 0.92 | |||||
| < 45 years | 11 (22) | 4 (20) | 7 (23.3) | 3 (16.7) | 8 (25) | ||
| ≥ 45 years | 39 (78) | 16 (80) | 23 (76.7) | 15 (83.3) | 24 (75) | ||
| Menopausal status | 0.131 | 0.009 | |||||
| Premenopausal | 42 (84) | 18 (90) | 24 (80) | 18 (100) | 24 (75) | ||
| Postmenopausal | 8 (16) | 2 (10) | 6 (20) | 0 (0) | 8 (25) | ||
| T category | 0.003 | 0.004 | |||||
| < 6 cms | 30 (60) | 7 (35) | 23 (76.7) | 6 (33.3) | 24 (75) | ||
| ≥ 6 cms | 20 (40) | 13 (65) | 7 (23.3) | 12 (66.7) | 8 (25) | ||
| Clinical nodal status | 0.001 | 0.001 | |||||
| cN0-cN1 | 36 (72) | 9 (45) | 27 (90) | 8 (44.4) | 28 (87.5) | ||
| cN2-cN3 | 14 (28) | 11 (55) | 3 (10) | 10 (55.6) | 4 (12.5) | ||
| Grade of tumor | 0.700 | 0.376 | |||||
| I | 14 (28) | 5 (25) | 9 (30) | 4 (22.2) | 10 (31.3) | ||
| II-III | 36 (72) | 15 (75) | 21 (70) | 14 (77.8) | 22 (68.7) | ||
| Clinical response | 0.002 | 0.002 | |||||
| cCR | 20 (40) | 2 (10) | 18 (60) | 2 (11.1) | 18 (56.3) | ||
| No cCR | 30 (60) | 18 (90) | 12 (40) | 16 (88.9) | 14 (43.7) | ||
| Pathological response | 0.007 | 0.006 | |||||
| pCR | 18 (36) | 2 (10) | 16 (53.3) | 2 (11.1) | 16 (50) | ||
| No pCR | 32 (64) | 18 (90) | 14 (46.7) | 16 (88.9) | 16 (50) |