FIG 4.

Effect of excluding predicted polynucleotide-binding regions (PBRs) on theoretical capsid pIs (colored circles) for 32 viruses. Box and whisker plots represent the range of empirical pIs found in the literature, while circles represent predicted pIs calculated without modification, as well as after excluding predicted PBRs. PBRs were predicted either via the structure-based prediction developed in this study identifying arginine-rich regions and beta turns, or by one of two available NA-binding prediction tools, Pprint (45, 46) or DRNApred (47, 48). A key to the virus abbreviations (x axis) is provided in Table 2.