Table 3:
Adjusted multivariable, BKMR, and quantile g-computation estimates for cord and maternal sera analyses.
| Cord Serum | ||||||
|---|---|---|---|---|---|---|
| BKMR* | ||||||
| n | Multivariable β (95% CI) |
Estimate (95% Credible Interval) |
PIP** | Qgcomp*** Estimate | ||
| log2(TSH) | 236 | |||||
| log2(PFOA) | 0.06 (−0.08, 0.19) | 0.013 (−0.087, 0.114) | 0.121 | 0.039 | ||
| log2(PFOS) | 0.09 (−0.06, 0.25) | 0.094 (−0.082, 0.271) | 0.836 | 0.070 | ||
| log2(PFNA) | 0.04 (−0.16, 0.24) | 0.005 (−0.079, 0.090) | 0.135 | 0.013 | ||
| log2(PFHxS) | 0.05 (−0.05, 0.16) | 0.003 (−0.059, 0.065) | 0.083 | −0.024 | ||
| Overall | 0.112 (−0.082, 0.305) | 0.098 (95% CI: −0.033, 0.230), p-value = 0.14 | ||||
| log2(TT4) | 231 | |||||
| log2(PFOA) | 0.03 (−0.02, 0.08) | 0.001 (−0.011, 0.012) | 0.016 | 0.016 | ||
| log2(PFOS) | 0.01 (−0.04, 0.07) | 0.000 (−0.009, 0.009) | 0.022 | 0.004 | ||
| log2(PFNA) | 0.002 (−0.07, 0.07) | 0.000 (−0.004, 0.004) | 0.005 | −0.021 | ||
| log2(PFHxS) | 0.02 (−0.01, 0.06) | 0.001 (−0.017, 0.020) | 0.032 | 0.015 | ||
| Overall | 0.002 (−0.021, 0.026) | 0.015 (95% CI: −0.036, 0.066), p-value = 0.57 | ||||
| log2(TT3) | 236 | |||||
| log2(PFOA) | −0.01 (−0.09, 0.06) | 0.000 (−0.004, 0.004) | 0.002 | −0.016 | ||
| log2(PFOS) | −0.02 (−0.10, 0.06) | 0.000 (−0.005, 0.005) | 0.006 | 0.040 | ||
| log2(PFNA) | −0.04 (−0.14, 0.07) | 0.000 (−0.008, 0.008) | 0.005 | −0.024 | ||
| log2(PFHxS) | −0.02 (−0.08, 0.03) | 0.000 (−0.010, 0.010) | 0.009 | −0.032 | ||
| Overall | −0.001 (−0.015, 0.014) | −0.032 (95% CI: −0.093, 0.029), p-value = 0.30 | ||||
| log2(FT4) | 236 | |||||
| log2(PFOA) | −0.01 (−0.04, 0.03) | 0.000 (−0.017, 0.017) | 0.165 | 0.015 | ||
| log2(PFOS) | −0.02 (−0.06, 0.02) | −0.003 (−0.024, 0.018) | 0.216 | −0.018 | ||
| log2(PFNA) | −0.01 (−0.07, 0.04) | −0.002 (−0.022, 0.018) | 0.157 | −0.012 | ||
| log2(PFHxS) | −0.01 (−0.04, 0.02) | −0.001 (−0.020, 0.019) | 0.190 | 0.007 | ||
| Overall | −0.006 (−0.039, 0.028) | −0.008 (95% CI: −0.045, 0.028), p-value = 0.66 | ||||
| log2(FT3) | 234 | |||||
| log2(PFOA) | −0.01 (−0.06, 0.03) | 0.000 (−0.010, 0.010) | 0.569 | −0.001 | ||
| log2(PFOS) | −0.03 (−0.07, 0.02) | 0.000 (−0.012, 0.012) | 0.569 | 0.011 | ||
| log2(PFNA) | −0.02 (−0.08, 0.04) | 0.000 (−0.012, 0.011) | 0.585 | −0.013 | ||
| log2(PFHxS) | −0.02 (−0.05, 0.02) | 0.000 (−0.011, 0.011) | 0.579 | −0.011 | ||
| Overall | 0.000 (−0.022, 0.021) | −0.024 (95% CI: −0.062, 0.013), p-value =0.20 | ||||
| Maternal Serum | ||||||
| BKMR* | ||||||
| n | Multivariable β (95% CI) |
Estimate (95% Credible Interval) |
PIP** | Qgcomp*** Estimate | ||
| log2(TSH) | 171 | |||||
| log2(PFOA) | 0.09 (−0.14, 0.33) | 0.046 (−0.164, 0.257) | 0.335 | 0.169 | ||
| log2(PFOS) | 0.02 (−0.24, 0.28) | 0.024 (−0.170, 0.218) | 0.393 | 0.011 | ||
| log2(PFNA) | −0.23 (−0.56, 0.10) | −0.068 (−0.294, 0.158) | 0.432 | −0.109 | ||
| log2(PFHxS) | −0.06 (−0.23, 0.11) | −0.044 (−0.262, 0.174) | 0.366 | −0.120 | ||
| Overall | −0.045 (−0.336, 0.247) | −0.049 (95% CI: −0.281, 0.184), p-value = 0.68 | ||||
| log2(TT4) | 171 | |||||
| log2(PFOA) | −0.03 (−0.10, 0.04) | −0.001 (−0.015, 0.014) | 0.023 | −0.019 | ||
| log2(PFOS) | 0.02 (−0.08, 0.08) | 0.000 (−0.009, 0.010) | 0.019 | 0.041 | ||
| log2(PFNA) | −0.07 (−0.17, 0.03) | −0.002 (−0.025, 0.022) | 0.034 | −0.045 | ||
| log2(PFHxS) | 0.00 (−0.05, 0.06) | 0.000 (−0.014, 0.014) | 0.024 | 0.006 | ||
| Overall | −0.002 (−0.035, 0.03) | −0.017 (95% CI: −0.075, 0.042), p-value = 0.58 | ||||
| log2(TT3) | 171 | |||||
| log2(PFOA) | −0.01 (−0.05, 0.04) | 0.000 (−0.002, 0.002) | 0.001 | 0.010 | ||
| log2(PFOS) | −0.02 (−0.07, 0.03) | 0.000 (−0.004, 0.003) | 0.001 | −0.004 | ||
| log2(PFNA) | −0.03 (−0.09, 0.03) | 0.000 (0.000, 0.000) | 0.000 | −0.020 | ||
| log2(PFHxS) | −0.01 (−0.04, 0.02) | 0.000 (0.000, 0.000) | 0.001 | −0.009 | ||
| Overall | 0.000 (−0.004, 0.004) | −0.024 (95% CI: −0.066, 0.018), p-value = 0.26 | ||||
| log2(FT4) | 171 | |||||
| log2(PFOA) | −0.01 (−0.06, 0.03) | −0.005 (−0.036, 0.026) | 0.179 | −0.017 | ||
| log2(PFOS) | 0.02 (−0.02, 0.07) | 0.005 (−0.027, 0.036) | 0.175 | 0.003 | ||
| log2(PFNA) | −0.01 (−0.07, 0.05) | −0.003 (−0.026, 0.021) | 0.224 | −0.005 | ||
| log2(PFHxS) | 0.02 (−0.01, 0.05) | 0.005 (−0.027, 0.038) | 0.240 | 0.023 | ||
| Overall | 0.003 (−0.042, 0.047) | 0.004 (95% CI: −0.044, 0.051), p-value = 0.88 | ||||
| log2(FT3) | 171 | |||||
| log2(PFOA) | −0.01 (−0.04, 0.01) | 0.000 (−0.003, 0.003) | 0.008 | 0.000 | ||
| log2(PFOS) | −0.03 (−0.06, 0.00) | −0.001 (−0.015, 0.012) | 0.052 | −0.009 | ||
| log2(PFNA) | −0.02 (−0.05, 0.02) | 0.000 (−0.005, 0.004) | 0.011 | −0.005 | ||
| log2(PFHxS) | −0.02 (−0.04, 0.00) | −0.001 (−0.012, 0.010) | 0.028 | −0.007 | ||
| Overall | −0.002 (−0.020, 0.015) | −0.022 (95% CI: −0.051, 0.007), p-value = 0.13 | ||||
*
BKMR: Bayesian kernel machine regression
**
PIP: Posterior inclusion probability
***
Qgcomp: Quantile g-computation
The models have been adjusted for each PFAS, maternal age at delivery, race/ethnicity, marital status at baseline, maternal education level, household income, mean log10-transformed cotinine, maternal alcohol usage during pregnancy, nulliparity, maternal body mass index based on pre-pregnancy weight in pounds, the child’s sex, gestational week at blood draw for PFAS measurement, and delivery mode. All predictors and continuous covariates were also centered to 0 and scaled to a standard deviation of 1 in the BKMR and quantile g-computation models.