Fig. 6.

Genetic or pharmacological inhibition of 3-MST reduces ischemia/reperfusion injury. % Infarcted Area (A) and % Area At Risk (AAR) (B) measured as described in the Methods in WT and 3-MST^−/− mice subjected to 30 min ischemia followed by 2 h reperfusion under the following conditions: Control, PreC (ischemic pre-conditioning), PostC (ischemic post-conditioning). % Infarcted Area (C) and % Area At Risk (D) in WT mice treated with either vehicle (veh) or the pharmacological inhibitor of 3-MST, I 3MT-3. Values are shown as mean ± SEM, n = 8–10/group (Control), n = 5–6/group (WT (veh), WT (I 3MT-3), PreC and PostC). *p < 0.05 vs indicated group.