Figure 6.

Effects of DHJS on protein expression of NF-κB, p38, AMPK, SIRT1, Bax, Bcl2, and c-caspase3 in IL-1β-induced chondrocytes. DHJS reduced IL-1β-induced NF-κB phosphorylation (a). DHJS reduced IL-1β-induced p38 phosphorylation (b). DHJS increased AMPK phosphorylation and SIRT1 expression in IL-1β-induced chondrocytes (c). DHJS reduced Bax and c-caspase3 expression and increased Bcl2 expression in IL-1β-induced chondrocytes (d). Data are expressed as mean ± SD (n = 3). ^∗p < 0.05, ^∗∗p < 0.01, and ^∗∗∗p < 0.001, compared between the marked groups.