Table 3.

Meta-regression analyses of effect e-therapy vs controls on depression and anxiety outcomes (posttreatment and follow-up).

Time point and outcome, variable					k a		B coefficient		95% CI		SE		P valueb		R2 (%)c
Posttreatment
	Depression
		Initial severity		26		0.07		−0.06 to 0.21		0.06		.26		4.15
		Percentage of males		26		-0.01		−0.02 to 0.00		0.01		.09		8.30
		Mean age (years)		26		0.00		−0.02 to 0.01		0.01		.58		0.95
		Mean number of sessions completed		17		0.02		0.00 to 0.05		0.01		.08		10.23
		Risk of bias		26		-0.01		−0.11 to 0.08		0.05		.77		0.28
Follow-upc
	Depression
		Initial severity		16		0.25		0.12 to 0.39		0.06		<.001		53.17
		Percentage of males		16		-0.01		−0.03 to 0.01		0.01		.13		11.64
		Mean age (years)		16		0.01		−0.01 to 0.04		0.01		.38		3.88
		Mean number of sessions completed		11		0.01		−0.06 to 0.08		0.03		.78		0.44
		Risk of bias		16		0.02		−0.11 to 0.14		0.06		.78		0.40
Posttreatment
	Anxietyd
		Initial severity		17		0.12		−0.07 to 0.31		0.09		.17		8.84
		Percentage of males		17		-0.01		−0.03 to 0.01		0.01		.24		5.85
		Mean age (years)		17		-0.01		−0.03 to 0.01		0.01		.43		3.03
		Mean number of sessions completed		11		0.02		0.00 to 0.05		0.01		.07		23.93
		Risk of bias		17		-0.01		−0.14 to 0.12		0.06		.85		0.18

^ak: number of comparisons.

^bAlpha threshold Bonferroni adjusted to P<.01 for multiple testing.

^cInsufficient number of comparisons and limited between-study heterogeneity to warrant moderator analyses of anxiety outcomes at follow-up.

^dR²: percentage of variance explained by the moderator.