fig 1.

Patient H.U.: 22-year-old woman with acute plaques and multiple neurologic signs and symptoms of 2 to 4 weeks' chronicity at first presentation of MS.

A–F, Multiple monophasic ring lesions are identified on T1-weighted contrast-enhanced (A) and FLAIR (B) images. Lesion centers show hypointensity on diffusion-weighted image (C) with corresponding increased diffusibility (brightness) on calculated ADC map (D), caused by increased water mobility in regions of acute inflammation. Reduction in anisotropy in these regions is present on calculated maps of eccentricity (E) and FA (F). Note that region of peripheral edema is readily differentiated from thin plaque rim on ADC map. ADC values: NAWM, 0.00081; left periventricular acute plaque center, 0.00211; left periventricular acute plaque rim, 0.00124. FA values: NAWM, 0.299; left periventricular acute plaque center, 0.111; left periventricular acute plaque rim, 0.162.