fig 4.

Patient B.O.: 53-year-old woman with 40-year history of MS, presenting with dementia. T2 hyperintensity and ADC elevation are apparent with loss of white matter anisotropy in multiple chronic periventricular and subcortical plaques.

A–E, Diffusion-weighted image (A), T2-weighted echo-planar image (B), ADC map (C), and calculated maps of eccentricity (D) and FA (E). ADC values: NAWM, 0.00097; right corona radiata chronic plaque, 0.00083; left periventricular chronic plaque, 0.00071. FA values: NAWM, 0.334; right corona radiata chronic plaque, 0.289; left periventricular chronic plaque, 0.445.