Table 2. The functions of CBXs and genes significantly associated with CBX alterations were predicted by the analysis of pathway in regulating gastric cancer.

Category	Term	Count	P value/false discovery rate	Genes
KEGG_Pathway	Systemic lupus erythematosus	5	P=1.61E-05	HIST4H4, HIST1H4A, HIST1H4E, H3F3A, HIST1H4F
	Signaling pathways regulating pluripotency of stem cells	5	P=1.91E-05	BMI1, PCGF5, PCGF2, PCGF6, PCGF1
	Alcoholism	5	P=4.83E-05	HIST4H4, HIST1H4A, HIST1H4E, H3F3A, HIST1H4F
	Viral carcinogenesis	4	P=0.001918327	HIST4H4, HIST1H4A, HIST1H4E, HIST1H4F
Reactome_Pathway	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	4	False discovery rate =2.90E-08	CBX2, CBX4, CBX6, CBX8
	SUMOylation of chromatin organization proteins	4	False discovery rate =6.00E-08	CBX2, CBX4, CBX5, CBX8
	Regulation of PTEN gene transcription	4	False discovery rate =6.98E-08	CBX2, CBX4, CBX6, CBX8
	Oxidative Stress Induced Senescence	4	False discovery rate =2.83E-07	CBX2, CBX4, CBX6, CBX8
	SUMOylation of DNA methylation proteins	3	False discovery rate =2.83E-07	CBX2, CBX4, CBX8
	SUMOylation of transcription cofactors	3	False discovery rate =1.83E-06	CBX2, CBX4, CBX8
	SUMOylation of RNA binding proteins	3	False discovery rate =1.83E-06	CBX2, CBX4, CBX8
	Generic Transcription Pathway	6	False discovery rate =2.07E-06	CBX2, CBX3, CBX4, CBX5, CBX6, CBX8
	SUMOylation of DNA damage response and repair proteins	3	False discovery rate =5.11E-06	CBX2, CBX4, CBX8
	Transcriptional Regulation by E2F6	2	False discovery rate =0.00012	CBX3, CBX5