Fig. 5.

RBD-mAbs interface and their protein ligand interaction fingerprints (PLIF) analysis. A) The binding interface of SARS-CoV mAbs are displayed with respect to the predicted epitopes on cRBD (Green = Epitope 1, Cyan = Epitope 2, Red = Epitope 3; explained in Fig. 4). B) PLIF analysis of the CR3014 and CR3022 mAbs with cRBD. C) CR3014 cluster around epitope 2, which is highly variable between sRBD (left) and cRBD (right). CR3022 cluster near epitope 3, which is conserved between cRBD and sRBD. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)