Table 3.
Rates of ischemic stroke/TIA and bleeding events during follow-up stratified by INR level.
| INR level | Ischemic stroke/TIA and bleeding events (per 100 person-years) | ||||
| Ischemic stroke/TIA | Major bleeding | Minor bleeding | Total bleeding | Ischemic stroke/TIA or major bleeding | |
| INR: international normalized ratio; TIA: transient ischemic attack. | |||||
| All (n = 2, 232) | |||||
| < 1.5 | 6.63 (4.41-9.59) | 1.18 (0.38-2.77) | 11.37 (8.39-15.08) | 12.56 (9.41-16.43) | 7.82 (5.38-10.98) |
| 1.5-2 | 1.78 (1.02-2.88) | 1.11 (0.53-2.04) | 10.88 (8.83-13.26) | 11.99 (9.83-14.47) | 2.89 (1.89-4.23) |
| 2-2.5 | 0.94 (0.47-1.68) | 1.45 (0.84-2.32) | 8.35 (6.78-10.18) | 9.80 (8.09-11.77) | 2.39 (1.59-3.45) |
| 2.5-3 | 0.68 (0.22-1.59) | 1.50 (0.75-2.68) | 10.89 (8.63-13.55) | 12.39 (9.97-15.20) | 2.18 (1.24-3.54) |
| 3-3.5 | 0.61 (0.07-2.21) | 4.28 (2.34-7.18) | 15.91 (11.88-20.85) | 20.19 (15.61-25.68) | 4.90 (2.80-7.95) |
| > 3.5 | 0.36 (0.01-2.03) | 20.03 (15.07-26.03) | 37.14 (30.24-45.03) | 57.17 (48.51-66.75) | 20.39 (15.38-26.44) |
| Total | 1.64 (2.41-3.52) | 2.92 (1.26-2.10) | 12.47 (11.38-13.64) | 15.39 (14.18-16.69) | 4.57 (3.92-5.30) |
| Age ≥ 70 yrs (n = 1, 083) | |||||
| < 1.5 | 10.71 (6.73-16.25) | 1.95 (0.53-5.00) | 12.18 (7.89-18.00) | 14.12 (9.47-20.32) | 12.66 (8.29-18.58) |
| 1.5-2 | 1.94 (0.84-3.82) | 1.45 (0.53-3.16) | 11.37 (8.33-15.13) | 12.82 (9.61-16.79) | 3.39 (1.85-5.69) |
| 2-2.5 | 1.42 (0.61-2.79) | 2.30 (1.23-3.94) | 8.33 (6.12-11.08) | 10.64 (8.12-13.69) | 3.72 (2.30-5.69) |
| 2.5-3 | 0.86 (0.18-2.50) | 2.57 (1.18-4.88) | 13.43 (9.87-17.86) | 16.00 (12.09-20.78) | 3.43 (1.77-5.99) |
| 3-3.5 | 0.65 (0.02-3.59) | 4.52 (1.18-9.31) | 18.06 (12.00-26.11) | 22.58 (15.73-31.40) | 5.16 (2.23-10.17) |
| > 3.5 | 0.71 (0.02-3.92) | 27.54 (19.53-37.55) | 43.08 (32.86-55.18) | 70.62 (57.30-85.65) | 28.25 (20.12-38.36) |
| Total | 2.35 (1.70-3.17) | 4.26 (3.37-5.32) | 13.94 (12.28-15.75) | 18.20 (16.30-20.28) | 6.61 (5.49-7.90) |
| Age < 70 yrs (n = 1, 149) | |||||
| < 1.5 | 2.77 (1.01-6.02) | 0.46 (0.01-2.57) | 10.61 (6.72-15.90) | 11.07 (1.09-16.46) | 3.23 (1.30-6.65) |
| 1.5-2 | 1.64 (0.71-3.23) | 0.82 (0.22-2.10) | 10.46 (7.78-13.74) | 11.28 (8.49-14.67) | 2.46 (1.27-4.30) |
| 2-2.5 | 0.49 (0.10-1.44) | 0.66 (0.18-1.68) | 8.37 (6.24-11.01) | 9.03 (6.80-11.76) | 1.15 (0.46-2.37) |
| 2.5-3 | 0.52 (0.06-1.88) | 0.52 (0.06-1.88) | 8.58 (5.90-12.04) | 9.10 (6.33-12.64) | 1.04 (0.28-2.66) |
| 3-3.5 | 0.58 (0.01-3.24) | 4.07 (1.64-8.39) | 13.97 (8.94-20.76) | 18.04 (12.25-25.58) | 4.66 (2.01-9.16) |
| > 3.5 | 0 | 12.03 (6.88-19.54) | 30.83 (22.12-41.82) | 42.86 (32.46-55.53) | 12.03 (6.88-19.54) |
| Total | 1.00 (0.61-1.54) | 1.70 (1.18-2.37) | 11.13 (9.72-12.69) | 12.83 (11.31-14.50) | 2.70 (2.03-3.52) |