Table 4.

The results of linear mixed model analysis to test the difference of INR levels in patients with and without outcomes based on repeated INR data.

	Mean INR	Standard error of the mean	Mean difference (95% CI)	Effect estimate (Beta)	Effect standard error	P-value
A P-value < 0.05 indicates statistical significance. The interaction effect between thromboembolic, bleeding, minor bleeding, and major bleeding event and time was non-significant (P > 0.05). ICH: intracranial hemorrhage; INR: international normalized ratio; TIA: transient ischemic attack.
Ischemic stroke/TIA	1.79	0.17	-0.60 (-0.93--0.28)	0.60	0.17	< 0.001
No ischemic stroke/TIA	2.40	0.01
Total bleeding	3.41	0.05	1.05 (0.94-1.16)	-1.05	0.05	< 0.001
No bleeding	2.37	0.01
Major bleeding	5.12	0.13	2.74 (2.50-2.99)	-2.74	0.13	< 0.001
No major bleeding	2.38	0.01
ICH	2.94	0.25	0.55 (0.06-1.03)	-0.55	0.25	0.028
No ICH	2.39	0.01
Minor bleeding	3.02	0.06	0.63 (0.51-0.75)	-0.63	0.06	< 0.001
No minor bleeding	2.38	0.01
Follow-up time point				2.45	0.02	< 0.001