Table 3.

Adjusted^* association between averaged log10 transformed maternal concentrations of DM^† and DE^‡ metabolite concentrations in nmol/g creatinine and brain volumes (N=441) and white matter microstructure (N=474) assessed at child age 10 years.

	Averaged DM metabolite concentrations in nmol/g creatinine				Averaged DE metabolite concentrations in nmol/g creatinine
Brain volumes	B	95%CI			B	95%CI
Total brain	12.81	−26.31	to	51.92	0.22	−28.98	to	29.42
Total gray	4.69	−18.75	to	28.13	−3.38	−20.88	to	14.12
Subcortical gray matter	0.26	−1.53	to	2.04	−0.69	−2.03	to	0.65
Cerebral white matter	8.16	−9.57	to	25.90	4.27	−8.98	to	17.53
Thalamus§	−0.36	−0.74	to	0.02	−0.18	−0.47	to	0.11
Caudate§	0.18	−0.18	to	0.55	−0.11	−0.38	to	0.16
Putamen§	0.42	0.00	to	0.85	−0.01	−0.33	to	0.31
Pallidum§	0.05	−0.10	to	0.20	−0.05	−0.16	to	0.06
Hippocampus§	−0.10	−0.35	to	0.16	0.02	−0.17	to	0.21
Amygdala§	0.05	−0.08	to	0.18	0.05	−0.05	to	0.15
Nucleus accumbens§	0.00	−0.07	to	0.07	0.00	−0.05	to	0.06
Cerebellum cortex§	−2.68	−6.51	to	1.15	−2.30	−5.16	to	0.57
Cerebellar white matter§	−0.08	−1.08	to	0.91	−0.46	−1.20	to	0.28
Corpus callosum§	−0.06	−0.27	to	0.16	−0.01	−0.17	to	0.15
White matter microstructure	B	95%CI			B	95%CI
Global FA	−1.00	−1.80	to	−0.20	−0.63	−1.24	to	−0.02
Global MD	0.13	0.04	to	0.21	0.06	0.00	to	0.13

Abbreviations: DM= Dimethyl alkyl phosphates, DE= Diethyl alkyl phosphates, FA= fractionalanisotropy, MD= mean diffusivity

^*Adjusted for age of child during the magnetic resonance imaging assessment, sex of child, and maternal age, ethnicity (Dutch, other-western and non-western), education (low, intermediate and high), income (low, middle and high), marital status, alcohol consumption during pregnancy (no alcohol consumption during pregnancy, alcohol consumption until pregnancy was known, occasionally alcohol consumption during pregnancy and frequently alcohol consumption during pregnancy), body mass index, parity (0, 1, 2+), and smoking use during pregnancy (no smoking during pregnancy, smoked until pregnancy wasknown, smoked during pregnancy).

^†DM is the sum of dimethylphosphate, dimethylthiophosphate, and dimethyldithiophosphate.

^‡DE is the sum of diethylphosphate, diethylthiophosphate, and diethyldithiophosphate.

^§Additionally adjusted for intracranial volume