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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Nucl Med Biol. 2020 May 12;92:171–183. doi: 10.1016/j.nucmedbio.2020.05.002

Scheme 1.

Scheme 1.

Synthesis of Boc2-iso-SGMTB, Boc2-MEGMTB tin precursor and the cold standard MEGMIB. a) 2-(trimethylsilyl)ethan-1-ol, DMAP, EDC, DCM; b) i: NBS, AIBN, DCE, ii: NaOAc, DMF, iii: NH3, MeOH; c) (Ph3P)2PdCl2, hexametheylditin, 1,4-dioxane; d) 1,3-bis(tert-butoxycarbonyl)guanidine, TPP, DIAD, THF; e) i: TBAF, THF, ii: 1-hydroxypyrrolidine-2,5-dione, EDC, DMAP, DCM; f) N-chlorosuccinimide, KI, DMF; g) 2-maleimidoethylamine hydrochloride, DIPEA, DMF; h) i: 2-maleimidoethylamine hydrochloride, DIPEA, DMF, ii: TFA.