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. Author manuscript; available in PMC: 2022 Jan 1.

Published in final edited form as: Nucl Med Biol. 2020 May 12;92:171–183. doi: 10.1016/j.nucmedbio.2020.05.002

Table 1.

Pair-labeled biodistribution of iso-[¹²⁵I]SGMIB-5F7 and [¹³¹I]MEGMIB-5F7GGC in athymic mice bearing Her2-expressing SKOV-3 xenografts.

	Percent injected dose per gram^c
	1 h		4 h		24 h
tissue	¹²⁵I^a	¹³¹I^b	¹²⁵I	¹³¹I	¹²⁵I	¹³¹I
Liver	4.88 ± 0.71	1.74 ± 0.45	2.12 ± 0.84	0.76 ± 0.36	0.46 ± 0.14	1.53 ± 0.55
Spleen	1.05 ± 0.51	0.36 ± 0.14	0.74 ± 0.23	0.20 ± 0.05	0.22 ± 0.16	0.65 ± 0.48
Lungs	2.50 ± 0.58	2.48 ± 0.51	1.08 ± 0.40	1.06 ± 0.39	0.84 ± 0.85	0.54 ± 0.60
Heart	0.49 ± 0.12	0.41 ± 0.11	0.11 ± 0.03	0.08 ± 0.02	0.03 ± 0.03	0.03 ± 0.02
Kidneys	41.82 ± 13.33	20.39 ± 5.34	2.88 ± 0.46	1.77 ± 0.28	0.12 ± 0.02	0.40 ± 0.14
Stomach	2.00 ± 0.66	0.94 ± 0.30	1.20 ± 0.64	0.61 ± 0.49	0.07 ± 0.05	0.09 ± 0.08
Sm. Int.	1.26 ± 0.27	2.09 ± 0.47	0.75 ± 0.27	0.31 ± 0.11	0.05 ± 0.01	0.09 ± 0.02
Lg. Int.	0.38 ± 0.15	0.52 ± 0.15	2.80 ± 0.99	3.20 ± 2.33	0.13 ± 0.03	0.18 ± 0.04
Muscle	0.29 ± 0.07	0.22 ± 0.08	0.08 ± 0.05	0.05 ± 0.03	0.01 ± 0.01	0.01 ± 0.01
Blood	0.83 ± 0.28	0.59 ± 0.18	0.22 ± 0.09	0.12 ± 0.03	0.17 ± 0.33	0.13 ± 0.10
Bone	0.69 ± 0.24	0.48 ± 0.23	0.18 ± 0.09	0.09 ± 0.02	0.13 ± 0.26	0.13 ± 0.10
Brain	0.06 ± 0.03	0.05 ± 0.02	0.02 ± 0.01	0.01 ± 0.01	0.00 ± 0.00	0.00 ± 0.00
Thyroid	1.25 ± 0.87	0.57 ± 0.44	1.79 ± 0.59	0.60 ± 0.20	2.03 ± 1.17	0.83 ± 0.48
Tumor	8.35 ± 2.66	8.43 ± 2.84	6.11 ± 1.56	6.11 ± 1.63	3.13 ± 1.52	3.60 ± 1.75

^a:

iso-[¹²⁵I]SGMIB-5F7.

^b:

[¹³¹I]MEGMIB-5F7GGC.

^c:

%ID/g, mean ± SD, n=5