Table 2.
Odds ratio (OR) and 95% confidence interval (CI) for behavioral difficulties in children according to per inter quartile range increase in the weighted quantile sum (WQS) index of prenatal PFAS mixtures .
| Behavioral difficulties | OR (95% CI)a |
||
|---|---|---|---|
| SDQ by parents at 7 years (N=1,506) | SDQ by parents at 11 years (N=1,303) | SDQ by children at 11 years (N=1,303) | |
| Total difficulties | 1.44 (1.10-1.89) | 1.19 (0.89-1.61) | 1.28 (0.96-1.70) |
| Internalizing difficulties | 1.14 (0.86-1.52) | 0.95 (0.72-1.24) | 1.25 (0.95-1.63) |
| Externalizing difficulties | 1.19 (0.91-1.56) | 1.21 (0.92-1.59) | 1.21 (0.93-1.57) |
OR: odds ratio; CI: confidence interval
a
A WQS index was created using all six types of PFAS to reflect the mixture exposure level.
Models were adjusted for sex, birth year, maternal age, parity, maternal social-occupational status, maternal pre-pregnancy BMI, gestational week of blood draw, smoking during the 1st trimester, and alcohol intake during the 1st trimester, and parent’s behavioral scores.