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. 2020 Oct 29;11:580636. doi: 10.3389/fimmu.2020.580636

Table 1.

Mimotopes of retinal autoantigen in uveitis.

Source Amino acid sequence of peptide/epitope Protein
Rotavirus  W  T  E  V  S  E  V  A  T  E  V Outer capsid protein
aa 591-601 (peptide Rota)
Bovine milk  S  E  E  S  A  E  V  A  T  E  E  V Bovine αs2-casein aa 73-84 (peptide Cas)
Retinal autoantigen F  L  G  E  L  T  S  S  E  V  A  T  E  V Human retinal S-Ag,
peptide PDSAg aa 341-354
HLA-B  A  L  N  E  D  L  S  S  W  T  A  A  D  T HLA-B, α1 domain
aa 125-138 (peptide B27PD)
Retinal autoantigen  V  T  I  Y  L  G  N Human retinal S-Ag
aa 26-32
M. bovis (BCG)  V  T  I  Y  L  G  N Invasion protein aa 433-439
Retinal autoantigen  V  G  T  P  A  E  Q  A Human IRBP aa 304-311
M. bovis (BCG)  V  G  T  P  A  E  V  A MabA protein aa 231-238
Retinal autoantigen  D  G  S  S  W  E  G Human IRBP, peptide R14
aa 1200-1206
M. bovis (BCG)  D  G  S  S  W  D  G Membrane acyltransferase
aa 173-179
Retinal autoantigen  D  S  L  S  P  E  A Human CRALBP aa 129-135
M. bovis (BCG)  D  S  L  S  P  E  A Polyketide synthase aa 997-1003

S-Ag, retinal soluble antigen; IRBP, interphotoreceptor retinoid-binding protein; CRALBP, cellular retinaldehyde-binding protein, M. bovis, Mycobacterium bovis. Amino acids identical with the sequence of the retinal autoantigen are marked by grey fields.