Figure 3.

Relative frequencies of CD8⁺ T cells subsets in PIRD patients. The frequency of CD45RA⁺CD27⁺CD8⁺ (naïve) T cells (A), HLA-DR⁺CD8⁺ (activated) T cells (B), CD45RA^-CD27^-CD8⁺ (T_EM) cells (C) and CD45RA⁺CD27^-CD8⁺ (T_EMRA) cells (D) in a cohort of 16 HD and 15 patients with dysregulatory syndrome PID were depicted. Horizontal lines represent the mean of each group. The distribution of the frequencies of CD45RA⁺CD27⁺CD8⁺ (naïve) T cells (E), HLA-DR⁺ CD8⁺ (activated) T cells (F), CD45RA^-CD27^-CD8⁺ (T_EM) cells (G) and CD45RA⁺CD27^-CD8⁺ (T_EMRA) cells (H) in each group of this cohort was also depicted. P1 (STAT1 GOF) and P11 (CVID) were under treatment (as detailed in Supplementary Table 1). Gray areas indicate the 10^th and 90^th percentiles of HD for each parameter. An unpaired parametric t-Student test with Welch´s correction was used in (A–C). An unpaired non-parametric t-Student test with Mann-Whitney U test was used in (D). a non-parametric test with Dunn’s post hoc was used in (E–H). *p < 0.05; **p < 0.01; ***, p < 0.001.