Fig. 1.

Comparison of top biofunctions in disease and disorder development with the in vitro studies (PCBs mixed, PCB-153 and PCB-138 alone), and from the 45-month-old Slovak children’s cohort, as generated through IPA analysis. The gene sets from each analysis were processed with same filter settings and were uploaded and run through the IPA Comparative Analysis module. The important disease and disorders that are represented here were at or above the threshold value (corresponding to a p value of 0.05, comparing high- and low-exposure groups). Fischer’s exact test was used to calculate this p-value determining the probability that each biological function and/or disease assigned to that dataset is due to chance alone.