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. Author manuscript; available in PMC: 2021 Nov 9.
Published in final edited form as: Dev Cell. 2020 Aug 28;55(3):314–327.e7. doi: 10.1016/j.devcel.2020.08.002

Figure 7.

Figure 7.

RND-catalyzed cholesterol transport in the Hh pathway

(A) Schematic of the prototypical prokaryotic H+-powered RND transporter, E.coli AcrB.

(B) DISP1 functions as a Na+-powered antiporter, transporting cholesterylated SHH from the outer leaflet of the plasma membrane and handing it off to extracellular SCUBE2.

(C, D) Two possible modes of K+-powered cholesterol transport by PTCH1. In (C), PTCH1 moves cholesterol between the two leaflets of the membrane, making it unavailable for SMO activation. In (D), PTCH1 transports cholesterol from SMO to the membrane, thus catalyzing SMO deactivation.