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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2020 Sep 2;47(6):597–612. doi: 10.1007/s10928-020-09713-0

Table 1.

Physiological model parameters for rabbit.

Total
Volume (L)
Plasma
Volume (L)
Blood Cell
Volume (L)
Interstitial
Volume (L)
Endosomal
Volume (L)
Cellular
Volume (L)
Plasma
Flow (L/h)
Blood Cell
Flow (L/h)
Lung 0.0170 0.00247 0.00123 0.00320 0.0000850 0.0100 21.2 10.6
Heart 0.00600 0.000231 0.000116 0.000600 0.0000300 0.00502 0.768 0.384
Kidney 0.0150 0.00158 0.000788 0.00300 0.0000750 0.0103 3.69 1.85
Muscle 1.35 0.0351 0.0176 0.162 0.00675 1.13 6.21 3.11
Skin 0.110 0.00209 0.00105 0.0332 0.000550 0.0711 1.63 0.813
Brain 0.0140 0.000518 0.000259 5.60E-06 0.0000700 0.0134 0.380 0.190
Adipose 0.120 0.00120 0.000600 0.0162 0.000600 0.10128 1.28 0.641
Thymus S. 0.00410 0.000228 0.000114 0.000697 2.05E-05 0.00374 0.0224 0.0112
Intestine L. 0.0600 0.00144 0.000720 0.00564 0.000300 0.0524 2.21 1.10
Intestine 0.0300 0.000720 0.000360 0.00282 0.000150 0.0262 0.564 0.282
Spleen 0.00100 0.000282 0.000141 0.000150 0.00000500 0.000583 0.360 0.180
Pancreas 0.00360 0.000648 0.000324 0.000432 0.0000180 0.00263 0.144 0.0720
Liver 0.100 0.0115 0.00575 0.0163 0.000500 0.0690 0.163 0.0815
Bone 0.310 0.0127 0.00636 0.0310 0.00155 0.264 1.86 0.930
Ly. Node 0.0103 -- -- -- -- 0.0103 -- --
Other 0.2493 0.0103 0.00517 0.0422 0.00123 0.230 1.89 0.943
Plasma 0.110 -- -- -- -- -- 21.2 --
Blood Cells 0.055 -- -- -- -- -- -- 10.6