Table 2.

Glossary of parameters used in the PBPK model

Parameter	Units	Definition
PLQi	L /h	Plasma flow to the tissue “i”
BCQi	L /h	Blood cell flow to the tissue “i”
Li	L /h	Lymph flow from the tissue “i”
VPlasma, VBC, VLymphNode	L	Volumes of the central plasma, central blood cell, and lymph node compartments
$V_i^V$, $V_i^{BC}$, $V_i^E$, $V_i^{IS}$, $V_i^C$	L	Volumes of the vascular, blood cell, endosomal, interstitial, and cellular compartments for the tissue “i”
CPlasma, CBC, CLymphNode	nM	Concentrations in the central plasma, central blood cell, and lymph node compartments
$C_i^V$, $C_i^{BC}$, $C_i^{E_{Unbound}}$, $C_i^{E_{Bound}}$, $C_i^{IS}$, $C_i^{C_{Bound}}$	nM	Concentrations in the vascular, blood cell, endosomal (Unbound and Bound), interstitial, and cellular (Bound) compartments for the tissue “i”
FcRn	M	Concentration of FcRn in the endosomal space
${\sigma }_i^V$, ${\sigma }_i^{IS}$	–	Vascular and lymph reflection coefficients
$K_{on}^{FcRn}$, $K_{on}^{Ag}$	1 /M/h	Association rate constants between mAb and FcRn and mAb and Antigen
$K_{off}^{FcRn}$, $K_{off}^{Ag}$	1/h	Dissociation rate constants between mAb and FcRn and mAb and Antigen
FR	–	Fraction of FcRn bound mAb that recycles to the vascular space
CLup	L/h/L	Rate of pinocytosis and exocytosis per unit endosomal space of the vascular endothelium
Kdeg	1/h	First-order degradation rate constant of FcRn-unbound mAb in the endosomal space