Table 5.

Glossary of parameters used in the ocular compartment of the PBPK model.

Parameter	Units	Definition
VCornea, VAH, VVH	L	Volumes of the cornea, aqueous humor, and vitreous humor compartments
Qeye	L /h	Blood flow to the eye
Leye	L /h	Lymph flow from the eye
ficb, fret, fcho	–	Fraction of total blood and total lymph flow entering and exiting the iris-ciliary body, retina, and choroid
QBF	L /h	Bulk flow of fluid from the anterior eye to the posterior eye
QVA	L /h	Flow of fluid from vitreous chamber to aqueous chamber
QPtA	L /h	Flow of fluid from plasma to aqueous humor (i.e. rate of aqueous humor production)
QAH	L /h	Flow of fluid from aqueous humor returning to plasma (i.e. rate of aqueous humor drainage)
σret, σcho	–	Bulk flow reflection coefficients in the retina and choroid
σaq	–	Plasma-to-aqueous humor reflection coefficient
PScor, PSlens, PSret, PScho	L/h	Permeability Surface Area products for mAb in cornea, lens, retina, and choroid