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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2020 Sep 2;47(6):597–612. doi: 10.1007/s10928-020-09713-0

Table 6.

Estimated dose amount administered in intravitreal dosing studies and SMAPE of the PBPK model in prediction of AUC in ocular tissues.

SMAPE
Estimated
Dose (mg)		 CV% Study Vitreous
Humor		 Aqueous
Humor		 Retina Plasma Iris/Ciliary
Body
0.754 8.03 Gadkar[28] 11.0 4.19 9.43 19.3
0.926 14.1 Bakri[25] 23.4 30.5 23.4
0.696 2.39 Sinapis[27] 15.4 14.7 72.7
0.343 15.6 Nomoto[26] 5.09 89.6 11.2 12.5 15.1