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. 2020 Feb 5;77(23):5031–5043. doi: 10.1007/s00018-020-03464-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Aβ42 oligomers are trafficked to lysosomes. Co-labelling with Lysotracker red shows that Aβ42-488 oligomers (a) localise to lysosomes with a similar distribution to 488-labelled ovalbumin (b). Orthogonal views also show green and red signal colocalisation in x, y and z. Cells were treated with either 10 μM Aβ42-488 oligomers for 24 h or 100 μg/mL Ovalbumin-488 for 3 h. Scale bar is 10 μm. c (left panel) Aligned and overlaid transmission electron microscopy images of a section through a neuron treated with 5 μM Aβ42 oligomers for 14 days showing large circular electron-dense structures (arrows). Note, the image is a composite of multiple images that are differentially contrasted to allow clear visualisation of cellular structures. A higher magnification of one region of interest (yellow box) is shown in the right panel. Scale bar 5 μm (inset 2 μm)