Table 4.

Excretion pattern of vericiguat and its metabolites^a

Analyte	Total (range),  %	Excretion in feces (range),  %	Excretion in urine (range),  %
Vericiguat	51.6 (46.0–62.6)	42.6 (38.3–46.5)	9.0 (6.1–16.1)
M-1	40.8 (30.3–47.4)	–	40.8 (30.3–47.4)
M-15	3.5 (2.1–4.8)	1.6 (0.3–2.5)	1.9 (1.6–2.3)
Other	1.9 (0.8–4.1)	1.0 (0.4–2.7)	0.9 (0.1–1.5)
Total recovery	98.3b (95.6–99.8)	45.2 (40.1–49.9)	53.1b (49.9–56.1)

^aResults from the human mass balance study

^bA difference (0.5% of dose) to the sum of vericiguat, M-1, M-15, and others resulted from not investigated urine samples at later timepoints due to low radioactivity