Table 2.

Summary of genome-scale metabolic models for Clostridium spp.

Organism	Acetogen	Metabolic model			References
		Genes	Reaction	Metabolites
C. acetobutylicum ATCC 824	N	432	502	479	iJL432 [157]
C. acetobutylicum ATCC 824	N	473	522	422	[262]
C. acetobutylicum ATCC 824	N	700	709	679	iFS700 [252]
C. acetobutylicum ATCC 824	N	490	794	707	iCac490 [196]
C. acetobutylicum DSM 792	N	N/A	592	444	[309]
C. acetobutylicum ATCC 824	N	802	1462	1137	iCac802 [50]
C. acetobutylicum ATCC 824	N	967	1231	1058	iCac967 [332]
C. beijerinckii NCIMB 8052	N	925	938	881	iCM925 [197]
C. butyricum IBUN 13A	N	641	891	701	iCbu641 [263]
C. cellulolyticum H10	N	431	621	603	iFS431 [253]
C. kluyveri	N	708	994	804	iCKL708 [342]
C. thermocellum ATCC 27405	N	432	577	525	iSR432 [250]
C. thermocellum DSM 1313	N	601	872	904	iAT601 [290]
C. thermocellum ATCC 27405	N	446	637	598	iCth446 [49]
C. autoethanogenum	Y	805	1002	1075	[189]
C. autoethanogenum	Y	786	1109	1097	iCLAU786 [300]
C. autoethanogenum	Y	699	755	772	MetaCLAU [216]
C. drakei	Y	771	922	854	iSL771 [271]
C. ljungdahlii	Y	637	785	698	iHN637 [206]
C. ljungdahlii	Y	680	809	718	iJL680a [177]
M. thermoacetica	Y	558	705	698	iAI558 [119]

^aiJL680 is the GSM model that serves as the basis for the ME-model iJL965-ME. iJL965-ME extends iJL680 by adding 196 protein-coding open reading frames (ORFs), 89 RNA genes, 576 transcription units, 19 types of rRNA modifications, 17 types of tRNA modifications, 735 protein complexes with updated stoichiometry, 219 modified protein complexes and 134 translocated proteins