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. 2020 May 25;59(11):1419–1431. doi: 10.1007/s40262-020-00896-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 3 — Metformin tissue concentrations. Upper panel: pseudodynamic whole-body positron emission tomography imaging of a representative patient following an intravenous microdose of ¹¹C-metformin [7]

© SNMMI. a–f Population predictions of metformin blood and tissue concentration–time profiles measured in the ¹¹C-metformin positron emission tomography study, compared to observed data [7]. Population prediction arithmetic means are shown as lines; the shaded areas illustrate the 68% population prediction intervals. Observed data are shown as dots (training dataset) or triangles (test dataset). Linear plots are presented in the ESM. Bl bladder, He heart, iv intravenous, K kidney, Liv liver, SG submandibular gland, SUV standardized uptake value = concentration [kBq/mL]·body weight [g]/injected dose [kBq]