Table S1. Differently expressed genes between the two clusters.
| Genes | P values | Mean expression value in Cluster_1 | Mean expression value in Cluster_2 |
|---|---|---|---|
| FAP | 1.22E-52 | −0.71219 | 0.42392 |
| FN1 | 1.47E-39 | −0.64355 | 0.383066 |
| COL8A2 | 1.86E-36 | −0.62956 | 0.374739 |
| TSPAN12 | 1.09E-33 | 0.774641 | −0.4611 |
| VEGFA | 2.49E-33 | 0.767452 | −0.45682 |
| TNFAIP2 | 2.64E-31 | 0.751268 | −0.44718 |
| TYMP | 4.53E-30 | −0.62808 | 0.373854 |
| PIK3R6 | 1.61E-29 | −0.57319 | 0.341186 |
| ESM1 | 3.09E-26 | 0.658365 | −0.39188 |
| MFGE8 | 1.02E-25 | −0.52427 | 0.312067 |
| PTK2 | 5.48E-25 | 0.69457 | −0.41343 |
| THBS1 | 2.35E-24 | −0.49913 | 0.297104 |
| ECM1 | 1.07E-23 | −0.53988 | 0.321357 |
| MMRN2 | 1.21E-22 | 0.590577 | −0.35153 |
| ARHGAP22 | 1.07E-21 | −0.53779 | 0.320115 |
| IL6 | 2.72E-21 | −0.51258 | 0.305104 |
| WARS | 3.85E-20 | −0.54455 | 0.324137 |
| COL15A1 | 2.52E-18 | −0.41217 | 0.245338 |
| ARHGAP24 | 4.2E-18 | −0.43441 | 0.258575 |
| ANGPTL3 | 4.82E-18 | 0.590072 | −0.35123 |
| CEMIP2 | 5.83E-18 | 0.524714 | −0.31233 |
| NRP1 | 6.06E-18 | −0.45278 | 0.269511 |
| ANGPT2 | 5.49E-17 | 0.489635 | −0.29145 |
| NRXN3 | 7.54E-16 | 0.52137 | −0.31034 |
| ANPEP | 8.2E-16 | −0.43563 | 0.259303 |
| VAV3 | 3.55E-15 | 0.534683 | −0.31826 |
| PARVA | 4.8E-15 | −0.41303 | 0.245851 |
| KRIT1 | 1.14E-14 | 0.530007 | −0.31548 |
| PLXND1 | 1.27E-14 | −0.39681 | 0.236198 |
| CXCR3 | 3.75E-14 | −0.42852 | 0.255069 |
| PTPRB | 4.31E-14 | 0.420305 | −0.25018 |
| MMP2 | 1.21E-13 | −0.37564 | 0.223598 |
| FLT1 | 1.81E-13 | 0.401674 | −0.23909 |
| COL8A1 | 2.02E-13 | −0.37136 | 0.22105 |
| SEMA4A | 2.2E-13 | 0.491908 | −0.2928 |
| FMNL3 | 3.48E-13 | −0.37989 | 0.226123 |
| ADGRA2 | 5.61E-13 | −0.34422 | 0.204892 |
| ANGPT4 | 2.62E-12 | 0.448416 | −0.26691 |
| DLL4 | 9.71E-12 | 0.366835 | −0.21835 |
| EPHA1 | 1.14E-11 | 0.463117 | −0.27567 |
| FGF1 | 2.43E-11 | −0.35539 | 0.211541 |
| PIK3CG | 3.08E-11 | −0.37258 | 0.221775 |
| JAM3 | 5.28E-10 | −0.32311 | 0.192326 |
| ZNF304 | 6.59E-10 | 0.413028 | −0.24585 |
| MINAR1 | 7.22E-10 | 0.392291 | −0.23351 |
| MMP19 | 7.84E-10 | 0.367841 | −0.21895 |
| HAND2 | 1.74E-09 | −0.33064 | 0.196807 |
| ZC3H12A | 1.99E-09 | 0.38305 | −0.22801 |
| FGF2 | 2.19E-09 | −0.32073 | 0.19091 |
| CIB1 | 9.77E-09 | 0.384205 | −0.22869 |
| CXCL17 | 1.22E-08 | 0.391253 | −0.23289 |
| VEGFC | 1.58E-08 | −0.31405 | 0.186933 |
| TNFRSF12A | 2.34E-08 | −0.32205 | 0.191699 |
| PROK1 | 2.72E-08 | 0.359058 | −0.21372 |
| COL4A2 | 4.02E-08 | −0.26925 | 0.160269 |
| HIF1A | 5.42E-08 | −0.32646 | 0.194324 |
| KDR | 6.94E-08 | 0.286836 | −0.17074 |
| HTATIP2 | 1.95E-07 | −0.33507 | 0.199448 |
| HSPG2 | 4.22E-07 | −0.24745 | 0.147291 |
| SHB | 9.83E-07 | −0.30112 | 0.179239 |
| NRXN1 | 1.98E-06 | −0.28212 | 0.167926 |
| FGF6 | 2.21E-06 | 0.126084 | −0.07505 |
| PRKD2 | 2.37E-06 | 0.31899 | −0.18987 |
| HRG | 2.76E-06 | 0.268654 | −0.15991 |
| PDCL3 | 3.42E-06 | 0.319955 | −0.19045 |
| APLNR | 3.52E-06 | −0.23848 | 0.141951 |
| SRPX2 | 4.98E-06 | 0.287026 | −0.17085 |
| VEGFD | 9.95E-06 | 0.305397 | −0.18178 |
| EREG | 1.37E-05 | −0.2746 | 0.163454 |
| AKT1 | 3.49E-05 | 0.278346 | −0.16568 |
| BCAS3 | 5.34E-05 | 0.27783 | −0.16538 |
| PECAM1 | 6.94E-05 | −0.1998 | 0.11893 |
| FLT4 | 0.000115 | 0.204357 | −0.12164 |
| CCBE1 | 0.000138 | −0.249 | 0.148212 |
| TNFSF12 | 0.000141 | −0.20855 | 0.124138 |
| ANGPT1 | 0.000177 | −0.22422 | 0.133465 |
| HBA1 | 0.000193 | 0.262918 | −0.1565 |
| EGFR | 0.000198 | −0.24009 | 0.142914 |
| XBP1 | 0.000208 | 0.235631 | −0.14026 |
| CSPG4 | 0.000265 | −0.20411 | 0.121496 |
| ACVRL1 | 0.000321 | −0.18018 | 0.107249 |
| RHOB | 0.000362 | 0.216142 | −0.12866 |
| AIMP1 | 0.000379 | 0.258381 | −0.1538 |
| EPAS1 | 0.000383 | 0.212453 | −0.12646 |
| COL4A1 | 0.000417 | −0.17544 | 0.104431 |
| OTULIN | 0.000423 | −0.23162 | 0.137869 |
| PDCD10 | 0.000471 | −0.23597 | 0.140461 |
| TNF | 0.000591 | −0.21641 | 0.128817 |
| PDCD6 | 0.000597 | 0.23889 | −0.1422 |
| PRKD1 | 0.000702 | 0.204308 | −0.12161 |
| UNC5B | 0.000942 | 0.206711 | −0.12304 |
| ANGPTL6 | 0.001225 | −0.20781 | 0.123699 |
| EPHA2 | 0.001262 | 0.207137 | −0.1233 |
| GDF2 | 0.001483 | 0.119507 | −0.07114 |
| EMC10 | 0.002135 | 0.203182 | −0.12094 |
| CD160 | 0.002441 | 0.201907 | −0.12018 |
| RAPGEF3 | 0.002685 | 0.182248 | −0.10848 |
| EFNA1 | 0.003462 | 0.195042 | −0.1161 |
| AGGF1 | 0.007101 | 0.186722 | −0.11114 |
| NOX5 | 0.007547 | 0.18537 | −0.11034 |
| TIE1 | 0.01076 | −0.12543 | 0.07466 |
| EPHB4 | 0.011818 | −0.16719 | 0.099516 |
| ITGB1BP1 | 0.018531 | −0.15539 | 0.092496 |
| ANGPTL4 | 0.019834 | 0.146825 | −0.0874 |
| RHOJ | 0.02072 | −0.11266 | 0.067058 |
| AAMP | 0.022248 | 0.159327 | −0.09484 |
| TEK | 0.02284 | −0.1134 | 0.067498 |
| PRKCA | 0.029006 | 0.141675 | −0.08433 |
| EFNB2 | 0.029184 | −0.13632 | 0.081143 |
| S1PR1 | 0.031866 | −0.10726 | 0.063843 |
| SEMA3E | 0.033715 | 0.145457 | −0.08658 |
| PIK3CA | 0.036101 | −0.13583 | 0.080854 |
| EPHB3 | 0.038304 | −0.13581 | 0.080837 |
| DAB2IP | 0.047238 | 0.130468 | −0.07766 |
| ECSCR | 0.049793 | −0.09987 | 0.059445 |