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. 2020 Nov 11;6:121. doi: 10.1038/s41420-020-00359-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a The line chart displays the expression levels of CRNDE in 29 APL (orange) and 350 (blue) samples from the TCGA and Beat AML cohorts in order from high to low. b Bar graph represents the percentage of non-APL AML samples with (NPM1⁺) or without (NPM1^-) NPM1 mutations in groups with high, medium or low expression of CRNDE, respectively. Based on the tertile of CRNDE expression in non-APL AML samples, the patients were divided into three groups: with high expression of CRNDE (n = 116), medium expression of CRNDE (n = 116), and low expression of CRNDE (n = 116). c Relative CRNDE expression was measured by qRT-PCR assays in indicated cells. d The expression levels were detected by qRT-PCR in NPM1-mutant OCI-AML3 cells by transfection of CRNDE shRNAs (left panel). CD11b cell surface expression was detected to determine the differentiated OCI-AML3 cells (right panel). Data represent the mean of three replicates ± s.d. *P < 0.05, **P < 0.01.