Table 1.
The diseases and functions associated with genes by CRNDE knockdown. (P < 0.05).
| Enriched biofunction | # of genes | Genesa |
|---|---|---|
| Hematological disease, hematological system development and function | ||
| Differentiation of hematopoietic progenitor cells | 21 | CEBPE, CEBPA, GATA2, JUNB, IRF1 |
| Activation, movement and chemotaxis of peripheral blood neutrophils or monocytes | 8 | ANXA1, CTSG, CCL5, CCR1, ADAM17 |
| Myelopoiesis of hematopoietic progenitor cells | 10 | HIST1H4A, HIST2H4A, HIST2H4B, STAT5B, IRF1 |
| Cellular growth and proliferation | ||
| Proliferation of leukemia and tumor cell lines | 239 | IGFBP4, ANXA1, KLF6, AATF, MYC, CDK2, CEBPB, IFI16 |
| Cell death and survival | ||
| Apoptosis of cancer cell and tumor cell lines | 183 | BBC3, BCL2A1, BCL2L11, BAK1, STAT5A, BIRC2, TP53 |
| Cell death of bone cancer and tumor cell lines | 227 | KLF9, MAPK7, IGF1R, IRF5, HOXA1, CDK2, CDK9 |
| Cell viability of tumor cell lines | 121 | BCL2A1, TGFB1, IGF1R, IGF2R, TNFSF13B |
aPart of CRNDE knockdown-affected genes in the enriched biofunctions.