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. 2020 Oct 29;13:568641. doi: 10.3389/fnmol.2020.568641

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Copyright © 2020 Popiolek, Izumi, Hopper, Dai, Miller, Shu, Zorumski and Mennerick.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mouse brain CYP46A1 and 24S-HC expression. CYP46A1 antibody was validated on whole brain lysate from CYP46A1 KO mice (A). Topographically distinct CYP46A1 rodent brain expression observed with highest expression in the striatum > hippocampus > cortex/cerebellum. Representative lanes from western blots are shown. (B) Brain region 24S-HC differential observed with highest 24S-HC detected in striatum/cortex > hippocampus > cerebellum (C). *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.