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. 2020 Oct 29;14:832. doi: 10.3389/fnins.2020.00832

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Copyright © 2020 Bortel, Pilgram, Yao and Shmuel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The amplitudes of cerebral blood volume responses associated with seizure-free responses to 4 Hz forepaw stimulation under different anesthesia regimes. A bar graph showing the peak amplitude of CBV normal responses sampled from the gray matter region that showed the highest response. The white bar to the left shows the amplitude of response to stimuli of 1.5 mA administered at 4 Hz under dexmedetomidine and isoflurane anesthesia (Dex + Iso; mean ± SEM, n = 60 trials from 3 SD rats). The gray and black bars show the amplitudes of responses to stimuli of 1.0 mA and 2.0 mA, respectively, administered at 4 Hz under dexmedetomidine and buprenorphine sedation (Dex + Bup; n = 60 trials from the same 3 SD rats). **p < 0.001; Tamhane’s test.