FIGURE 2.

Cerebral blood oxygenation responses evoked by forepaw stimulation. (A) Cerebral blood oxygenation response evoked by stimulation of the contralateral forepaw. To the left, the spatial responses before (the 1 s before stimulus onset), during (9–10 s following stimulus onset), and after (9–10 s following the cessation of the stimulus) the 10 s-long forepaw stimulation period. The reference for obtaining these responses was imaged between 3 and 1 seconds before stimulus onset. Note that positive responses are indicated in indexed yellow and red colors, representing increases in blood oxygenation. To the right are two time-courses presenting the corresponding temporal responses from two regions (blue and red ROIs in panel C) within the activated area. The stimulation period between 0 and 10 seconds is marked by a dark bar. (B) Maps of the blood oxygenation changes during a response that evoked a seizure, from before, during, and after the 10 s-long forepaw stimulation period (exact time periods are as in A). To the right are two time-courses presenting the corresponding temporal responses from two regions (blue and red ROIs in panel C) within the activated area. (C) The imaged cortical surface with the two ROIs used for sampling the time-courses presented in A and B.