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. 2020 Oct 29;14:832. doi: 10.3389/fnins.2020.00832

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Copyright © 2020 Bortel, Pilgram, Yao and Shmuel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Forepaw stimulation administered at 8Hz induces epileptic activity in SD rats under dexmedetomidine and buprenorphine. The data presented in this figure were obtained from the same 3 rats whose responses to forepaw stimulation with different parameters are presented in Figure 6. (A) Top: LFP responses to 8 Hz & 1 mA forepaw stimulation. Note the seizures induced by the stimulus in the first and third trials. Bottom: A magnified view of the seizure recorded in the third trial. (B) Top: LFP responses to 8 Hz & 2 mA forepaw stimulation. Note the seizures induced by the stimulus in the first, fourth, and seventh trials. Bottom: A magnified view of the seizure recorded in the fourth trial. (C) The number of seizures recorded in each of the 3 rats whose responses to forepaw stimulation are presented in Figures 6 and 7. The number of seizures is presented as a function of time after the initiation of the dexmedetomidine administration. The stimulation parameters used for each pair of consecutive blocks are presented at the upper part of the panel.