TABLE 1.

Average number of rats and mice with seizures and average number of seizures per run according to anesthesia regime and stimulation parameters.

Species and Stimulation Type	Anesthesia Regime	Stimulation parameters
		4 Hz						6 Hz		8 Hz
		1 mA		1.5 mA		2 mA		2 mA		1 mA		2 mA
		Animals with seizures	No. of seizures per run	Animals with seizures	No. of seizures per run	Animals with seizures	No. of seizures per run	Animals with seizures	No. of seizures per run	Animals with seizures	No. of seizures per run	Animals with seizures	No. of seizures per run
SD Rats Forepaw stim	Dex and Bup	0/3	–			0/3	–			3/3	1.50 ± 0.81	7/9	2.14 ± 0.40
	Dex and Bup measured with ECoG											5/6	3.04 ± 0.42
	Dex and Bup without Ketamine											3/3	2.37 ± 0.35
	Dex and Iso without Bup			0/3	–							2/4	1.88 ± 0.44
LE Rats Forepaw stim	Dex and Bup											5/5	3.73 ± 0.50
C57 Mice Forepaw stim	Dex and Bup					0/5	–	0/5	–			0/5	–

The first column presents the species and strain (SD rats, LE rats or C57 mice) and the type of stimulation, i.e., forepaw stimulation. The second column presents the anesthesia regime, i.e., dexmedetomidine with buprenorphine sedation (Dex and Bup), dexmedetomidine with buprenorphine sedation without ketamine (Dex and Bup without Ketamine), and dexmedetomidine with isoflurane without buprenorphine (Dex and Iso without Bup). All neurophysiology data were recorded using a linear probe, except for the data presented in the second row labeled ‘Dex and Bup measured with ECoG‘ which were recorded using electrocorticography arrays. The experiments in this row, whose anesthesia regime is labeled in red font were presented in detail in Bortel et al. (2019). The 3rd, 5th, 7th, 9th, 11th, and 13th columns present the number of rats/mice with seizures and the 4th, 6th, 8th, 10th, 12th, and 14th columns present the average number of seizures per run (including all runs in rats and mice that had or did not have seizures). Results are expressed as a mean ± SEM.